Details of the Target

General Information of Target

Target ID LDTP02378
Target Name Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)
Gene Name IFIT2
Gene ID 3433
Synonyms
CIG-42; G10P2; IFI54; ISG54; Interferon-induced protein with tetratricopeptide repeats 2; IFIT-2; ISG-54 K; Interferon-induced 54 kDa protein; IFI-54K; P54
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYL
KHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKV
KHVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAI
ASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEAL
EKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKVFQVMN
LRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKE
FSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAK
MRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE
Target Bioclass
Other
Family
IFIT family
Subcellular location
Cytoplasm
Function
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
Uniprot ID
P09913
Ensemble ID
ENST00000371826.4
HGNC ID
HGNC:5409

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K271(0.48)  LDD0274  [1]
STPyne
 Probe Info  		K126(10.00); K148(4.44); K271(5.19); K294(6.87)  LDD0277  [1]
IPM
 Probe Info  		C149(0.00); C54(0.00); C73(0.00)  LDD0241  [2]
DBIA
 Probe Info  		C54(3.48); C149(4.92); C73(2.62)  LDD3311  [3]
BTD
 Probe Info  		C149(0.55)  LDD2096  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		C54(0.00); C149(0.00)  LDD0148  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 T cell-activated C289(20.00)  LDD1704  [7]
 LDCM0023  KB03 8505C C149(2.01)  LDD2666  [3]
 LDCM0024  KB05 G361 C54(3.48); C149(4.92); C73(2.62)  LDD3311  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C149(0.55)  LDD2096  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C160(0.85)  LDD2120  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C160(0.55)  LDD2128  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C160(0.80)  LDD2143  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) IFIT family P09914
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) IFIT family O14879

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.