Details of the Target

General Information of Target

Target ID LDTP02371
Target Name Tumor-associated calcium signal transducer 2 (TACSTD2)
Gene Name TACSTD2
Gene ID 4070
Synonyms
GA733-1; M1S1; TROP2; Tumor-associated calcium signal transducer 2; Cell surface glycoprotein Trop-2; Membrane component chromosome 1 surface marker 1; Pancreatic carcinoma marker protein GA733-1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGS
GMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCN
QTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLF
RERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRG
GLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNR
RKSGKYKKVEIKELGELRKEPSL
Target Type
Successful
Target Bioclass
Other
Family
EPCAM family
Subcellular location
Membrane
Function May function as a growth factor receptor.
TTD ID
T17629
Uniprot ID
P09758
DrugMap ID
TTP2HE5
Ensemble ID
ENST00000371225.4
HGNC ID
HGNC:11530
ChEMBL ID
CHEMBL3856163

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K138(2.85); K231(10.00)  LDD0274  [1]
STPyne
 Probe Info  		K138(9.94); K231(7.00); K267(0.83); K305(2.96)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K231(4.22); K138(5.06); K84(5.29)  LDD3494  [2]
DBIA
 Probe Info  		C44(1.25)  LDD3311  [3]
BTD
 Probe Info  		C145(0.53)  LDD2106  [4]
IA-alkyne
 Probe Info  		C66(0.00); C145(0.00); C108(0.00); C44(0.00)  LDD0162  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
NAIA_5
 Probe Info  		C66(0.00); C44(0.00); C145(0.00); C108(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0634  CY-0357 Hep-G2 C66(0.67)  LDD2228  [6]
 LDCM0022  KB02 A2780 C44(1.85)  LDD2254  [3]
 LDCM0023  KB03 A2780 C66(1.71); C145(1.68)  LDD2671  [3]
 LDCM0024  KB05 G361 C44(1.25)  LDD3311  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C145(0.53)  LDD2106  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 1-3 (KRTAP1-3) KRTAP type 1 family Q8IUG1
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 5-2 (KRTAP5-2) KRTAP type 5 family Q701N4
Late cornified envelope protein 2C (LCE2C) LCE family Q5TA81

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sacituzumab Govitecan . DB12893
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Skb264 Antibody drug conjugate DOS62C

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264