Details of the Target

General Information of Target

Target ID LDTP02347
Target Name Fructose-1,6-bisphosphatase 1 (FBP1)
Gene Name FBP1
Gene ID 2203
Synonyms
FBP; Fructose-1,6-bisphosphatase 1; FBPase 1; EC 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1; Liver FBPase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Target Bioclass
Enzyme
Family
FBPase class 1 family
Function
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Uniprot ID
P09467
Ensemble ID
ENST00000375326.9
HGNC ID
HGNC:3606
ChEMBL ID
CHEMBL3975

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K334(9.09); K73(6.07)  LDD0277  [1]
Probe 1
 Probe Info  		Y58(25.25); Y227(28.41); Y241(10.65)  LDD3495  [2]
DBIA
 Probe Info  		C39(2.88)  LDD3338  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [4]
NAIA_5
 Probe Info  		C39(0.00); C282(0.00); C93(0.00)  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C39(1.38)  LDD2265  [3]
 LDCM0023  KB03 AU565 C282(1.68)  LDD2682  [3]
 LDCM0024  KB05 MV4-11 C39(2.88)  LDD3338  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fructose-1,6-bisphosphatase 1 (FBP1) FBPase class 1 family P09467
Fructose-1,6-bisphosphatase isozyme 2 (FBP2) FBPase class 1 family O00757
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endothelial PAS domain-containing protein 1 (EPAS1) . Q99814
Hypoxia-inducible factor 1-alpha (HIF1A) . Q16665
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR2 (FXR2) FMR1 family P51116
Myc box-dependent-interacting protein 1 (BIN1) . O00499

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine Phosphate Small molecular drug DB00131
Investigative
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
25-anhydroglucitol-16-biphosphate Small molecular drug DB02778
4-amino-n-[(2-sulfanylethyl)Carbamoyl]Benzenesulfonamide Small molecular drug DB08484
Fructose-6-phosphate Small molecular drug DB04493
Mb-07803 Small molecular drug DB05053
25-dichloro-n-(5-chloro-13-benzoxazol-2-yl)Benzenesulfonamide . DB07312
25-dichloro-n-[5-methoxy-7-(6-methoxypyridin-3-yl)-13-benzoxazol-2-yl]Benzenesulfonamide . DB07321
Managlinat Dialanetil . DB05518
Mdl-29951 . DB04175
N-[7-(3-aminophenyl)-5-methoxy-13-benzoxazol-2-yl]-25-dichlorobenzenesulfonamide . DB07270
{4-[3-(67-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol . DB02848

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264