Details of the Target
General Information of Target
| Target ID | LDTP02336 | |||||
|---|---|---|---|---|---|---|
| Target Name | Matrilysin (MMP7) |
|
||||
| Gene Name | MMP7 | |||||
| Gene ID | 4316 | |||||
| Synonyms |
MPSL1; PUMP1; Matrilysin; EC 3.4.24.23; Matrin; Matrix metalloproteinase-7; MMP-7; Pump-1 protease; Uterine metalloproteinase |
|||||
| 3D Structure | ||||||
| Sequence |
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLK
EMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDL PHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAF APGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGD PQNFKLSQDDIKGIQKLYGKRSNSRKK |
|||||
| Target Type |
Successful
|
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Peptidase M10A family
|
|||||
| Subcellular location |
Secreted, extracellular space, extracellular matrix
|
|||||
| Function | Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase. | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C87(4.25) | LDD3375 | [1] | |
Competitor(s) Related to This Target