General Information of Target

Target ID LDTP02334
Target Name Cystatin-SA (CST2)
Gene Name CST2
Gene ID 1470
Synonyms
Cystatin-SA; Cystatin-2; Cystatin-S5
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAWPLCTLLLLLATQAVALAWSPQEEDRIIEGGIYDADLNDERVQRALHFVISEYNKATE
DEYYRRLLRVLRAREQIVGGVNYFFDIEVGRTICTKSQPNLDTCAFHEQPELQKKQLCSF
QIYEVPWEDRMSLVNSRCQEA
Target Bioclass
Other
Family
Cystatin family
Subcellular location
Secreted
Function Thiol protease inhibitor.
Uniprot ID
P09228
Ensemble ID
ENST00000304725.3
HGNC ID
HGNC:2474

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C104(1.57)  LDD2263  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AGS C104(1.57)  LDD2263  [1]
 LDCM0023  KB03 AGS C104(1.83)  LDD2680  [1]
 LDCM0024  KB05 AGS C104(1.79)  LDD3097  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840