Details of the Target
General Information of Target
| Target ID | LDTP02272 | |||||
|---|---|---|---|---|---|---|
| Target Name | All-trans-retinol dehydrogenase [NAD(+)] ADH4 (ADH4) | |||||
| Gene Name | ADH4 | |||||
| Gene ID | 127 | |||||
| Synonyms |
ADH2; All-trans-retinol dehydrogenase [NAD(+)] ADH4; EC 1.1.1.105; Alcohol dehydrogenase 2; Alcohol dehydrogenase 4; Alcohol dehydrogenase class II pi chain |
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| 3D Structure | ||||||
| Sequence |
MGTKGKVIKCKAAIAWEAGKPLCIEEVEVAPPKAHEVRIQIIATSLCHTDATVIDSKFEG
LAFPVIVGHEAAGIVESIGPGVTNVKPGDKVIPLYAPLCRKCKFCLSPLTNLCGKISNLK SPASDQQLMEDKTSRFTCKGKPVYHFFGTSTFSQYTVVSDINLAKIDDDANLERVCLLGC GFSTGYGAAINNAKVTPGSTCAVFGLGGVGLSAVMGCKAAGASRIIGIDINSEKFVKAKA LGATDCLNPRDLHKPIQEVIIELTKGGVDFALDCAGGSETMKAALDCTTAGWGSCTFIGV AAGSKGLTIFPEELIIGRTINGTFFGGWKSVDSIPKLVTDYKNKKFNLDALVTHTLPFDK ISEAFDLMNQGKSVRTILIF |
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| Target Bioclass |
Enzyme
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| Family |
Zinc-containing alcohol dehydrogenase family, Class-II subfamily
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| Subcellular location |
Cytoplasm
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| Function |
Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IPM Probe Info |
 |
C99(0.00); C105(0.00); C113(0.00); C23(0.00) | LDD0241 | [1] | |
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DBIA Probe Info |
 |
C265(2.62); C99(1.85) | LDD3424 | [2] | |
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Ox-W18 Probe Info |
 |
N.A. | LDD2175 | [3] | |
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W1 Probe Info |
 |
C99(0.00); C246(0.00) | LDD0236 | [1] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References