Details of the Target

General Information of Target

Target ID LDTP02265
Target Name Neutrophil elastase (ELANE)
Gene Name ELANE
Gene ID 1991
Synonyms
ELA2; Neutrophil elastase; EC 3.4.21.37; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; HLE; Medullasin; PMN elastase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase S1 family, Elastase subfamily
Subcellular location
Cytoplasmic vesicle, phagosome
Function
Serine protease that modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Promotes cleavage of GSDMB, thereby inhibiting pyroptosis. Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae.
TTD ID
T40332
Uniprot ID
P08246
DrugMap ID
TTPLTSQ
Ensemble ID
ENST00000263621.2
HGNC ID
HGNC:3309
ChEMBL ID
CHEMBL248

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C151(3.54); C187(1.92)  LDD3333  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CMK C254(1.10); C187(1.08)  LDD2302  [1]
 LDCM0023  KB03 Kasumi-1 C151(4.63); C254(1.77); C187(1.55)  LDD2831  [1]
 LDCM0024  KB05 MOLM-13 C151(3.54); C187(1.92)  LDD3333  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840