Details of the Target

General Information of Target

Target ID LDTP02245
Target Name Beta-microseminoprotein (MSMB)
Gene Name MSMB
Gene ID 4477
Synonyms
PRSP; Beta-microseminoprotein; Immunoglobulin-binding factor; IGBF; PN44; Prostate secreted seminal plasma protein; Prostate secretory protein of 94 amino acids; PSP-94; PSP94; Seminal plasma beta-inhibin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETC
TCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII
Target Type
Clinical trial
Target Bioclass
Other
Family
Beta-microseminoprotein family
Subcellular location
Secreted
TTD ID
T07374
Uniprot ID
P08118
DrugMap ID
TTYH1ZK
Ensemble ID
ENST00000581478.5
HGNC ID
HGNC:7372

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC12 SNV: p.Y23N .
LNCaP clone FGC SNV: p.S110C .
SNU449 SNV: p.W112C .
SW480 SNV: p.W112Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C107(2.71)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 OV-90 C107(1.89)  LDD2546  [1]
 LDCM0023  KB03 OV-90 C107(1.57)  LDD2963  [1]
 LDCM0024  KB05 OV-90 C107(2.71)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840