Details of the Target
General Information of Target
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
---|---|---|---|---|---|
TH211 Probe Info |
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Y188(20.00); Y113(8.30) | LDD0260 | [1] | |
DBIA Probe Info |
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C49(2.69) | LDD3397 | [2] | |
4-Iodoacetamidophenylacetylene Probe Info |
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C98(0.00); C49(0.00) | LDD0038 | [3] | |
IA-alkyne Probe Info |
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C98(0.00); C49(0.00) | LDD0036 | [3] | |
Lodoacetamide azide Probe Info |
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C98(0.00); C49(0.00) | LDD0037 | [3] | |
Compound 10 Probe Info |
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N.A. | LDD2216 | [4] | |
Compound 11 Probe Info |
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N.A. | LDD2213 | [4] |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
Tyrosine-protein kinase SYK (SYK) | Tyr protein kinase family | P43405 | |||
Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyr protein kinase family | P43403 |
Transporter and channel
Protein name | Family | Uniprot ID | |||
---|---|---|---|---|---|
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) | NIP3 family | Q12983 |
Other
The Drug(s) Related To This Target
Approved
Drug Name | Drug Type | External ID | |||
---|---|---|---|---|---|
Mosunetuzumab | Antibody | DB15434 | |||
Teplizumab | Antibody | DB06606 | |||
Catumaxomab | . | DB06607 | |||
Muromonab | . | D0C6PS | |||
Teclistamab | . | DB16655 |
Phase 2
Drug Name | Drug Type | External ID | |||
---|---|---|---|---|---|
Ertumaxomab | Antibody | D0O2JI | |||
Resimmune | . | D0C3TI |
Phase 1
Drug Name | Drug Type | External ID | |||
---|---|---|---|---|---|
Autologous T-cell Therapy | Antibody | D04UWG | |||
Mt-110 | Antibody | D00YOV |
Investigative
Drug Name | Drug Type | External ID | |||
---|---|---|---|---|---|
Odronextamab | . | DB16684 |
References