General Information of Target

Target ID LDTP02221
Target Name T-cell surface glycoprotein CD3 epsilon chain (CD3E)
Gene Name CD3E
Gene ID 916
Synonyms
T3E; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface antigen T3/Leu-4 epsilon chain; CD antigen CD3e
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQ
HNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCE
NCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERP
PPVPNPDYEPIRKGQRDLYSGLNQRRI
Target Type
Successful
Target Bioclass
Transporter and channel
Subcellular location
Cell membrane
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
TTD ID
T87075
Uniprot ID
P07766
DrugMap ID
TTZAT79
Ensemble ID
ENST00000361763.9
HGNC ID
HGNC:1674
ChEMBL ID
CHEMBL1975

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info 
Y188(20.00); Y113(8.30)  LDD0260  [1]
DBIA
 Probe Info 
C49(2.69)  LDD3397  [2]
4-Iodoacetamidophenylacetylene
 Probe Info 
C98(0.00); C49(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info 
C98(0.00); C49(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info 
C98(0.00); C49(0.00)  LDD0037  [3]
Compound 10
 Probe Info 
N.A.  LDD2216  [4]
Compound 11
 Probe Info 
N.A.  LDD2213  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 DEL C49(1.23)  LDD2315  [2]
 LDCM0023  KB03 Jurkat C49(2.00)  LDD2826  [2]
 LDCM0024  KB05 PF-382 C49(2.69)  LDD3397  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Tyrosine-protein kinase ZAP-70 (ZAP70) Tyr protein kinase family P43403
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) EPS8 family Q8TE68
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Cytoplasmic protein NCK2 (NCK2) . O43639
Mucin-15 (MUC15) . Q8N387
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mosunetuzumab Antibody DB15434
Teplizumab Antibody DB06606
Catumaxomab . DB06607
Muromonab . D0C6PS
Teclistamab . DB16655
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ertumaxomab Antibody D0O2JI
Resimmune . D0C3TI
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Autologous T-cell Therapy Antibody D04UWG
Mt-110 Antibody D00YOV
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Odronextamab . DB16684

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279