General Information of Target

Target ID LDTP02214
Target Name Decorin (DCN)
Gene Name DCN
Gene ID 1634
Synonyms
SLRR1B; Decorin; Bone proteoglycan II; PG-S2; PG40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQC
HLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKV
SPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIE
LGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAAS
LKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH
NNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK
Target Type
Literature-reported
Target Bioclass
Other
Family
Small leucine-rich proteoglycan (SLRP) family, SLRP class I subfamily
Subcellular location
Secreted, extracellular space, extracellular matrix
Function May affect the rate of fibrils formation.
TTD ID
T67883
Uniprot ID
P07585
DrugMap ID
TTB3XAN
Ensemble ID
ENST00000052754.10
HGNC ID
HGNC:2705

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.S309Ter .
NCIH2286 SNV: p.D87H .
RKO Insertion: p.M148NfsTer12 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C67(2.73)  LDD2361  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hs 839.T C67(2.73)  LDD2361  [1]
 LDCM0023  KB03 Hs 839.T C67(3.81)  LDD2778  [1]
 LDCM0024  KB05 Hs 839.T C67(3.96)  LDD3195  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840