Details of the Target

General Information of Target

Target ID LDTP02187
Target Name Vitamin K-dependent protein S (PROS1)
Gene Name PROS1
Gene ID 5627
Synonyms
PROS; Vitamin K-dependent protein S
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRVLGGRCGALLACLLLVLPVSEANFLSKQQASQVLVRKRRANSLLEETKQGNLERECIE
ELCNKEEAREVFENDPETDYFYPKYLVCLRSFQTGLFTAARQSTNAYPDLRSCVNAIPDQ
CSPLPCNEDGYMSCKDGKASFTCTCKPGWQGEKCEFDINECKDPSNINGGCSQICDNTPG
SYHCSCKNGFVMLSNKKDCKDVDECSLKPSICGTAVCKNIPGDFECECPEGYRYNLKSKS
CEDIDECSENMCAQLCVNYPGGYTCYCDGKKGFKLAQDQKSCEVVSVCLPLNLDTKYELL
YLAEQFAGVVLYLKFRLPEISRFSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIE
VQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDINKPGPLFKPENGL
LETKVYFAGFPRKVESELIKPINPRLDGCIRSWNLMKQGASGIKEIIQEKQNKHCLVTVE
KGSYYPGSGIAQFHIDYNNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLV
DSTSEKSQDILLSVENTVIYRIQALSLCSDQQSHLEFRVNRNNLELSTPLKIETISHEDL
QRQLAVLDKAMKAKVATYLGGLPDVPFSATPVNAFYNGCMEVNINGVQLDLDEAISKHND
IRAHSCPSVWKKTKNS
Target Bioclass
Other
Subcellular location
Secreted
Function Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.
Uniprot ID
P07225
Ensemble ID
ENST00000348974.5
HGNC ID
HGNC:9456

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C666(3.80)  LDD3311  [1]
IPM
 Probe Info  		C88(1.77)  LDD1702  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C666(1.13)  LDD1507  [4]
 LDCM0276  AC17 HEK-293T C666(1.10)  LDD1515  [4]
 LDCM0281  AC21 HEK-293T C666(1.06)  LDD1520  [4]
 LDCM0285  AC25 HEK-293T C666(1.32)  LDD1524  [4]
 LDCM0289  AC29 HEK-293T C666(0.97)  LDD1528  [4]
 LDCM0294  AC33 HEK-293T C666(1.12)  LDD1533  [4]
 LDCM0298  AC37 HEK-293T C666(0.94)  LDD1537  [4]
 LDCM0303  AC41 HEK-293T C666(1.20)  LDD1542  [4]
 LDCM0307  AC45 HEK-293T C666(0.87)  LDD1546  [4]
 LDCM0311  AC49 HEK-293T C666(1.31)  LDD1550  [4]
 LDCM0312  AC5 HEK-293T C666(0.82)  LDD1551  [4]
 LDCM0316  AC53 HEK-293T C666(0.93)  LDD1555  [4]
 LDCM0320  AC57 HEK-293T C666(0.98)  LDD1559  [4]
 LDCM0325  AC61 HEK-293T C666(1.09)  LDD1564  [4]
 LDCM0248  AKOS034007472 HEK-293T C666(0.90)  LDD1511  [4]
 LDCM0356  AKOS034007680 HEK-293T C666(1.02)  LDD1570  [4]
 LDCM0371  CL102 HEK-293T C666(0.79)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C666(1.04)  LDD1579  [4]
 LDCM0380  CL110 HEK-293T C666(1.03)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C666(0.93)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C666(0.81)  LDD1592  [4]
 LDCM0393  CL122 HEK-293T C666(0.92)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C666(0.89)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C666(0.78)  LDD1605  [4]
 LDCM0404  CL17 HEK-293T C666(1.13)  LDD1608  [4]
 LDCM0407  CL2 HEK-293T C666(0.83)  LDD1611  [4]
 LDCM0409  CL21 HEK-293T C666(1.24)  LDD1613  [4]
 LDCM0414  CL26 HEK-293T C666(0.85)  LDD1618  [4]
 LDCM0417  CL29 HEK-293T C666(1.18)  LDD1621  [4]
 LDCM0422  CL33 HEK-293T C666(0.81)  LDD1626  [4]
 LDCM0431  CL41 HEK-293T C666(1.17)  LDD1635  [4]
 LDCM0435  CL45 HEK-293T C666(0.76)  LDD1639  [4]
 LDCM0440  CL5 HEK-293T C666(1.04)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C666(0.93)  LDD1645  [4]
 LDCM0444  CL53 HEK-293T C666(1.15)  LDD1647  [4]
 LDCM0448  CL57 HEK-293T C666(1.09)  LDD1651  [4]
 LDCM0454  CL62 HEK-293T C666(0.80)  LDD1657  [4]
 LDCM0457  CL65 HEK-293T C666(1.19)  LDD1660  [4]
 LDCM0461  CL69 HEK-293T C666(0.85)  LDD1664  [4]
 LDCM0467  CL74 HEK-293T C666(0.95)  LDD1670  [4]
 LDCM0470  CL77 HEK-293T C666(1.21)  LDD1673  [4]
 LDCM0475  CL81 HEK-293T C666(1.01)  LDD1678  [4]
 LDCM0480  CL86 HEK-293T C666(0.90)  LDD1683  [4]
 LDCM0483  CL89 HEK-293T C666(1.02)  LDD1686  [4]
 LDCM0484  CL9 HEK-293T C666(0.98)  LDD1687  [4]
 LDCM0488  CL93 HEK-293T C666(0.98)  LDD1691  [4]
 LDCM0493  CL98 HEK-293T C666(0.92)  LDD1696  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C88(1.77)  LDD1702  [2]
 LDCM0427  Fragment51 HEK-293T C666(1.15)  LDD1631  [4]
 LDCM0022  KB02 A2058 C475(2.14)  LDD2253  [1]
 LDCM0023  KB03 A2058 C475(3.27)  LDD2670  [1]
 LDCM0024  KB05 G361 C666(3.80)  LDD3311  [1]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981
Optineurin (OPTN) . Q96CV9

The Drug(s) Related To This Target

Approved
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Drotrecogin Alfa BiotechDrug DB00055
Kappadione Small molecular drug DB09332
Menadione Small molecular drug DB00170
Sodium Tetradecyl Sulfate Small molecular drug DB00464

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402