Details of the Target
General Information of Target
| Target ID | LDTP02183 | |||||
|---|---|---|---|---|---|---|
| Target Name | Thyroid peroxidase (TPO) | |||||
| Gene Name | TPO | |||||
| Gene ID | 7173 | |||||
| Synonyms |
Thyroid peroxidase; TPO; EC 1.11.1.8 |
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| 3D Structure | ||||||
| Sequence |
MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL |
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| Target Type |
Successful
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| Target Bioclass |
Enzyme
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| Family |
Peroxidase family, XPO subfamily
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| Subcellular location |
Membrane; Cell surface
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| Function | Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4). | |||||
| TTD ID | ||||||
| Uniprot ID | ||||||
| DrugMap ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| CAL51 | SNV: p.R206L | DBIA Probe Info | |||
| CCFSTTG1 | SNV: p.G331R; p.S332I | . | |||
| COLO792 | SNV: p.A294D | DBIA Probe Info | |||
| DU145 | SNV: p.L324Q | . | |||
| HCT15 | SNV: p.R616S | . | |||
| IGROV1 | SNV: p.S507N | . | |||
| MCC26 | SNV: p.P275S | . | |||
| NCIH1793 | Insertion: p.R646QfsTer23 | . | |||
| NCIH196 | SNV: p.Q113R | . | |||
| NCIH2172 | SNV: p.L173M; p.P179T | . | |||
| NCIH82 | SNV: p.C800S | . | |||
| NUGC3 | Deletion: p.F718Ter | DBIA Probe Info | |||
| SUIT2 | SNV: p.Q235Ter | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C898(1.38) | LDD3311 | [1] | |
Competitor(s) Related to This Target