Details of the Target

General Information of Target

Target ID LDTP02176
Target Name Tyrosine 3-monooxygenase (TH)
Gene Name TH
Gene ID 7054
Synonyms
TYH; Tyrosine 3-monooxygenase; EC 1.14.16.2; Tyrosine 3-hydroxylase; TH
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQGAPGPSLTGSPWPGTAAPAASYTPTP
RSPRFIGRRQSLIEDARKEREAAVAAAAAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPR
ATKPSALSRAVKVFETFEAKIHHLETRPAQRPRAGGPHLEYFVRLEVRRGDLAALLSGVR
QVSEDVRSPAGPKVPWFPRKVSELDKCHHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEI
AFQYRHGDPIPRVEYTAEEIATWKEVYTTLKGLYATHACGEHLEAFALLERFSGYREDNI
PQLEDVSRFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCC
HELLGHVPMLADRTFAQFSQDIGLASLGASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYG
AGLLSSYGELLHCLSEEPEIRAFDPEAAAVQPYQDQTYQSVYFVSESFSDAKDKLRSYAS
RIQRPFSVKFDPYTLAIDVLDSPQAVRRSLEGVQDELDTLAHALSAIG
Target Type
Successful
Target Bioclass
Enzyme
Family
Biopterin-dependent aromatic amino acid hydroxylase family
Subcellular location
Cytoplasm, perinuclear region
Function
Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of cathecolamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (Ref.18 ). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity. Positively regulates the regression of retinal hyaloid vessels during postnatal development. {|Ref.18}.; [Isoform 5]: Lacks catalytic activity.; [Isoform 6]: Lacks catalytic activity.
TTD ID
T62390
Uniprot ID
P07101
DrugMap ID
TTUHP71
Ensemble ID
ENST00000333684.9
HGNC ID
HGNC:11782
ChEMBL ID
CHEMBL1969

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C433(2.14)  LDD3340  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Kelly C433(1.44); C279(2.19); C341(2.22)  LDD2417  [1]
 LDCM0023  KB03 Kelly C433(2.31); C279(3.47); C341(3.90)  LDD2834  [1]
 LDCM0024  KB05 NB1 C433(2.14)  LDD3340  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840