Details of the Target
General Information of Target
| Target ID | LDTP02173 | |||||
|---|---|---|---|---|---|---|
| Target Name | Glia-derived nexin (SERPINE2) | |||||
| Gene Name | SERPINE2 | |||||
| Gene ID | 5270 | |||||
| Synonyms |
PI7; PN1; Glia-derived nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2 |
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| 3D Structure | ||||||
| Sequence |
MNWHLPLFLLASVTLPSICSHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIAS
VLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNAS EIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTR LVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYN FIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVA QTDLKEPLKVLGITDMFDSSKANFAKITTGSENLHVSHILQKAKIEVSEDGTKASAATTA ILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP |
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| Target Bioclass |
Other
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| Family |
Serpin family
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| Subcellular location |
Secreted, extracellular space
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| Function | Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
OPA-S-S-alkyne Probe Info |
 |
K131(0.13) | LDD3494 | [1] | |
|
DBIA Probe Info |
 |
C162(2.02) | LDD3332 | [2] | |
|
BTD Probe Info |
 |
C136(0.42) | LDD2128 | [3] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References