Details of the Target

General Information of Target

Target ID LDTP02157
Target Name Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)
Gene Name CEACAM5
Gene ID 1048
Synonyms
CEA; Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD antigen CD66e
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLVHNLPQ
HLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFY
TLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWV
NNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVLYGPDAP
TISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQ
AHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNN
QSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNELSVDHSDPVILNVLYGPDDPTI
SPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQAN
NSASGHSRTTVKTITVSAELPKPSISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQS
LPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISP
PDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNL
ATGRNNSIVKSITVSASGTSPGLSAGATVGIMIGVLVGVALI
Target Type
Clinical trial
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, CEA family
Subcellular location
Cell membrane
Function
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
TTD ID
T16601
Uniprot ID
P06731
DrugMap ID
TTY6DTE
Ensemble ID
ENST00000221992.11
HGNC ID
HGNC:1817
ChEMBL ID
CHEMBL3712881

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IPC298 SNV: p.E336K .
Ishikawa (Heraklio) 02 ER Deletion: p.K470del .
MCC13 SNV: p.P334L .
MEWO SNV: p.P390S .
NCIH2286 Deletion: p.N454TfsTer83 .
RKN SNV: p.P142S .
RPMI8226 Deletion: p.R546_F559del .
TCCSUP Substitution: p.S296L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C215(1.31)  LDD3312  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX390 C215(1.70)  LDD2273  [1]
 LDCM0023  KB03 A2780 C215(1.36)  LDD2671  [1]
 LDCM0024  KB05 HMCB C215(1.31)  LDD3312  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) CEA family P06731

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sar408701 Antibody drug conjugate D05TBQ
Phase 2
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Labetuzumab I-131 Antibody D0XP4A
Pentacea Antibody D0A3JJ
Bdc-1001 Antibody drug conjugate D1XI9E
Car-t Cells Targeting Cea CAR T Cell Therapy D0T5DC
Cap1-6d Small molecular drug D02UKX
Ceavac Vaccine D0O5XF
Idm-2101 Vaccine D03QMY
Avx701 . D05ENG
Ct84.66 . D0H5MS
Gi-6207 . D0L7VC
Phase 1
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
123-iodine-labeled Mfe-23 Antibody D0T5LQ
Cigb-m3 Antibody D0Z0EP
Neo-201 Antibody D7K5XP
Anti-cea Car-t Cells CAR T Cell Therapy D00KDQ
Anti-cea-car T CAR T Cell Therapy D0S1QN
Car-t Cells Targeting Cea CAR T Cell Therapy D0L6HU
Cea Car-t CAR T Cell Therapy DR0M3F
Amg 211 . D0P9UX
Mv-cea . D0U1WP
Rg7813 . D0M3GK
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ict-037 Antibody D05GIO
Hll1-fab-a3b3 Vaccine D00SJN
Labetuzumab . DB05097
S-[(1-hydroxy-2255-tetramethyl-25-dihydro-1h-pyrrol-3-yl)Methyl] Methanesulfonothioate . DB08217
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ksb-303 Antibody D0S0DU

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264