Details of the Target

General Information of Target

Target ID LDTP02119
Target Name Thyroxine-binding globulin (SERPINA7)
Gene Name SERPINA7
Gene ID 6906
Synonyms
TBG; Thyroxine-binding globulin; Serpin A7; T4-binding globulin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPFLYLVLLVLGLHATIHCASPEGKVTACHSSQPNATLYKMSSINADFAFNLYRRFTVE
TPDKNIFFSPVSISAALVMLSFGACCSTQTEIVETLGFNLTDTPMVEIQHGFQHLICSLN
FPKKELELQIGNALFIGKHLKPLAKFLNDVKTLYETEVFSTDFSNISAAKQEINSHVEMQ
TKGKVVGLIQDLKPNTIMVLVNYIHFKAQWANPFDPSKTEDSSSFLIDKTTTVQVPMMHQ
MEQYYHLVDMELNCTVLQMDYSKNALALFVLPKEGQMESVEAAMSSKTLKKWNRLLQKGW
VDLFVPKFSISATYDLGATLLKMGIQHAYSENADFSGLTEDNGLKLSNAAHKAVLHIGEK
GTEAAAVPEVELSDQPENTFLHPIIQIDRSFMLLILERSTRSILFLGKVVNPTEA
Target Bioclass
Other
Family
Serpin family
Subcellular location
Secreted
Function Major thyroid hormone transport protein in serum.
Uniprot ID
P05543
Ensemble ID
ENST00000327674.8
HGNC ID
HGNC:11583
ChEMBL ID
CHEMBL3843

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPIAA_L
 Probe Info  		N.A.  LDD0031  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 24 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Clofibrate Small molecular drug DB00636
Conjugated Estrogens Small molecular drug DB00286
Dantrolene Small molecular drug DB01219
Diamorphine Small molecular drug DB01452
Ethotoin Small molecular drug DB00754
Floxuridine Small molecular drug DB00322
Fluorouracil Small molecular drug DB00544
Fosphenytoin Small molecular drug DB01320
Furosemide Small molecular drug DB00695
Heparin Small molecular drug DB01109
Levothyroxine Small molecular drug DB00451
Liothyronine Small molecular drug DB00279
Liotrix Small molecular drug DB01583
Meclofenamic Acid Small molecular drug DB00939
Mephenytoin Small molecular drug DB00532
Mitotane Small molecular drug DB00648
Niacin Small molecular drug DB00627
Phenytoin Small molecular drug DB00252
Tamoxifen Small molecular drug DB00675
Tegafur Small molecular drug DB09256
Copper . DB09130
Synthetic Conjugated Estrogens A . DB09317
Synthetic Conjugated Estrogens B . DB09318
Thyroid Porcine . DB09100
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
5-fluorouridine . DB01629
Nrp409 . DB05235

References

1 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647