Details of the Target

General Information of Target

Target ID LDTP02093
Target Name Galectin-2 (LGALS2)
Gene Name LGALS2
Gene ID 3957
Synonyms
Galectin-2; Gal-2; Beta-galactoside-binding lectin L-14-II; HL14; Lactose-binding lectin 2; S-Lac lectin 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGELEVKNMDMKPGSTLKITGSIADGTDGFVINLGQGTDKLNLHFNPRFSESTIVCNSL
DGSNWGQEQREDHLCFSPGSEVKFTVTFESDKFKVKLPDGHELTFPNRLGHSHLSYLSVR
GGFNMSSFKLKE
Target Type
Literature-reported
Target Bioclass
Other
Function This protein binds beta-galactoside. Its physiological function is not yet known.
TTD ID
T40728
Uniprot ID
P05162
DrugMap ID
TTRHK90
Ensemble ID
ENST00000215886.6
HGNC ID
HGNC:6562
ChEMBL ID
CHEMBL5977

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C75(0.00); C57(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C57(0.94)  LDD3487  [2]
Acrolein
 Probe Info  		N.A.  LDD0224  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A498 C57(1.00)  LDD2259  [2]
 LDCM0023  KB03 VMRC-RCW C57(1.03)  LDD3070  [2]
 LDCM0024  KB05 VMRC-RCW C57(0.94)  LDD3487  [2]
 LDCM0109  NEM HeLa N.A.  LDD0224  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-2 (SDCBP2) . Q9H190

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Beta-d-glucose Small molecular drug DB02379

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.