Details of the Target
General Information of Target
| Target ID | LDTP02089 | |||||
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| Target Name | Plasma protease C1 inhibitor (SERPING1) |
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| Gene Name | SERPING1 | |||||
| Gene ID | 710 | |||||
| Synonyms |
C1IN; C1NH; Plasma protease C1 inhibitor; C1 Inh; C1Inh; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1 |
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| 3D Structure | ||||||
| Sequence |
MASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPIL
EVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTG SFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQ VLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPDLAIRDTFVNAS RTLYSSSPRVLSNNSDANLELINTWVAKNTNNKISRLLDSLPSDTRLVLLNAIYLSAKWK TTFDPKKTRMEPFHFKNSVIKVPMMNSKKYPVAHFIDQTLKAKVGQLQLSHNLSLVILVP QNLKHRLEDMEQALSPSVFKAIMEKLEMSKFQPTLLTLPRIKVTTSQDMLSIMEKLEFFD FSYDLNLCGLTEDPDLQVSAMQHQTVLELTETGVEAAAASAISVARTLLVFEVQQPFLFV LWDQQHKFPVFMGRVYDPRA |
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| Target Type |
Successful
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| Target Bioclass |
Other
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| Family |
Serpin family
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| Subcellular location |
Secreted
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| Function |
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
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Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
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| A375 | SNV: p.E85A | . | |||
| C32 | SNV: p.W299Ter | . | |||
| EOL1 | SNV: p.A75S | DBIA Probe Info | |||
| HT115 | SNV: p.L60M | . | |||
| LOXIMVI | Substitution: p.S150F | . | |||
| NCIH146 | SNV: p.N254S | . | |||
| REH | SNV: p.Q485H | . | |||
| SW403 | SNV: p.A292D | . | |||
| TGBC1TKB | SNV: p.S296R | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C210(5.15) | LDD3368 | [1] | |
Competitor(s) Related to This Target