Details of the Target

General Information of Target

Target ID	LDTP02082
Target Name	Interleukin-5 (IL5)
Gene Name	IL5
Gene ID	3567
Synonyms	Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNH QLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQ EFLGVMNTEWIIES
Target Type	Successful
Target Bioclass	Cytokine and receptor
Family	IL-5 family
Subcellular location	Secreted
Function	Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.
TTD ID	T78585
Uniprot ID	P05113
DrugMap ID	TTPREZD
Ensemble ID	ENST00000231454.6
HGNC ID	HGNC:6016
ChEMBL ID	CHEMBL1169600

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IPM Probe Info			N.A.	LDD0241	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Cytokine and receptor

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Cytokine receptor common subunit beta (CSF2RB)				Type I cytokine receptor family	P32927
Interleukin-5 receptor subunit alpha (IL5RA)				Type I cytokine receptor family	Q01344

The Drug(s) Related To This Target

Approved

Click To Hide/Show 3 Drug(s) Interacting with This Target

Investigative

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Pranlukast				Small molecular drug	DB01411
Sophoricoside				Small molecular drug	D07CEU

References

1	Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.