Details of the Target

General Information of Target

Target ID LDTP02073
Target Name Apolipoprotein D (APOD)
Gene Name APOD
Gene ID 347
Synonyms
Apolipoprotein D; Apo-D; ApoD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVMLLLLLSALAGLFGAAEGQAFHLGKCPNPPVQENFDVNKYLGRWYEIEKIPTTFENGR
CIQANYSLMENGKIKVLNQELRADGTVNQIEGEATPVNLTEPAKLEVKFSWFMPSAPYWI
LATDYENYALVYSCTCIIQLFHVDFAWILARNPNLPPETVDSLKNILTSNNIDVKKMTVT
DQVNCPKLS
Target Bioclass
Other
Family
Calycin superfamily, Lipocalin family
Subcellular location
Secreted
Function
APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
Uniprot ID
P05090
Ensemble ID
ENST00000343267.8
HGNC ID
HGNC:612

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C185(1.97)  LDD3395  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A101D C185(1.75)  LDD2250  [1]
 LDCM0023  KB03 BRX330 C185(2.65)  LDD2688  [1]
 LDCM0024  KB05 PC-3 C185(1.97)  LDD3395  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840