Details of the Target

General Information of Target

Target ID LDTP02026
Target Name Thy-1 membrane glycoprotein (THY1)
Gene Name THY1
Gene ID 7070
Synonyms
Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD antigen CD90
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNLAISIALLLTVLQVSRGQKVTSLTACLVDQSLRLDCRHENTSSSPIQYEFSLTRETKK
HVLFGTVGVPEHTYRSRTNFTSKYNMKVLYLSAFTSKDEGTYTCALHHSGHSPPISSQNV
TVLRDKLVKCEGISLLAQNTSWLLLLLLSLSLLQATDFMSL
Target Bioclass
Immunoglobulin
Subcellular location
Cell membrane
Function May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Uniprot ID
P04216
Ensemble ID
ENST00000284240.10
HGNC ID
HGNC:11801

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(1.36)  LDD3387  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 42-MG-BA C28(1.18)  LDD2244  [1]
 LDCM0023  KB03 8305C C28(1.65)  LDD2665  [1]
 LDCM0024  KB05 OVKATE C28(1.36)  LDD3387  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853