Details of the Target

General Information of Target

Target ID LDTP01965
Target Name Vitamin D-binding protein (GC)
Gene Name GC
Gene ID 2638
Synonyms
Vitamin D-binding protein; DBP; VDB; Gc protein-derived macrophage activating factor; Gc-MAF; GcMAF; Gc-globulin; Group-specific component; Gc; Vitamin D-binding protein-macrophage activating factor; DBP-maf
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQV
SQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERK
LCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTK
SYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLA
QKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCC
QEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVF
LSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKK
KLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL
Target Bioclass
Other
Family
ALB/AFP/VDB family
Subcellular location
Secreted
Function Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Uniprot ID
P02774
Ensemble ID
ENST00000273951.13
HGNC ID
HGNC:4187
ChEMBL ID
CHEMBL2259

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT29 SNV: p.A318V .
L428 SNV: p.K388N .
MDAMB468 SNV: p.T108I .
MEWO SNV: p.E302K DBIA    Probe Info 
MOLT4 SNV: p.R50G IA-alkyne    Probe Info 
NCIH2172 SNV: p.G20V .
PC9 SNV: p.A318S .
SNU423 SNV: p.K292N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K120(7.69)  LDD0277  [1]
DBIA
 Probe Info  		C141(2.05)  LDD3316  [2]
Acrolein
 Probe Info  		N.A.  LDD0225  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C407(0.00); C145(0.00); C286(0.00); C122(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C122(0.00); C286(0.00); C407(0.00); C145(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C407(0.00); C145(0.00); C122(0.00); C286(0.00)  LDD0037  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C122(0.85)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C122(1.26)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C122(1.10)  LDD1509  [5]
 LDCM0276  AC17 HEK-293T C122(0.93)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C122(1.00)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C122(1.23)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C122(1.23)  LDD1518  [5]
 LDCM0285  AC25 HEK-293T C122(1.02)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C122(1.08)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C122(1.13)  LDD1526  [5]
 LDCM0290  AC3 HEK-293T C122(1.02)  LDD1529  [5]
 LDCM0294  AC33 HEK-293T C122(0.99)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C122(1.17)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C122(1.18)  LDD1535  [5]
 LDCM0303  AC41 HEK-293T C122(0.92)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C122(1.31)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C122(1.03)  LDD1544  [5]
 LDCM0311  AC49 HEK-293T C122(0.96)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C122(1.09)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C122(1.08)  LDD1553  [5]
 LDCM0320  AC57 HEK-293T C122(0.88)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C122(1.19)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C122(1.04)  LDD1561  [5]
 LDCM0356  AKOS034007680 HEK-293T C122(0.88)  LDD1570  [5]
 LDCM0371  CL102 HEK-293T C122(1.13)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C122(1.09)  LDD1576  [5]
 LDCM0375  CL106 HEK-293T C122(0.94)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C122(0.90)  LDD1580  [5]
 LDCM0380  CL110 HEK-293T C122(1.01)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C122(0.91)  LDD1585  [5]
 LDCM0384  CL114 HEK-293T C122(1.09)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C122(1.07)  LDD1589  [5]
 LDCM0388  CL118 HEK-293T C122(1.11)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C122(1.00)  LDD1593  [5]
 LDCM0393  CL122 HEK-293T C122(0.91)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C122(0.95)  LDD1598  [5]
 LDCM0397  CL126 HEK-293T C122(1.16)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C122(1.01)  LDD1602  [5]
 LDCM0401  CL14 HEK-293T C122(1.01)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C122(0.90)  LDD1606  [5]
 LDCM0404  CL17 HEK-293T C122(0.84)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C122(1.30)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C122(1.11)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C122(0.96)  LDD1611  [5]
 LDCM0414  CL26 HEK-293T C122(1.00)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C122(0.85)  LDD1619  [5]
 LDCM0417  CL29 HEK-293T C122(0.89)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C122(0.83)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C122(1.06)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C122(0.98)  LDD1624  [5]
 LDCM0428  CL39 HEK-293T C122(0.85)  LDD1632  [5]
 LDCM0431  CL41 HEK-293T C122(0.93)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C122(1.10)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C122(1.09)  LDD1637  [5]
 LDCM0440  CL5 HEK-293T C122(0.87)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C122(1.05)  LDD1645  [5]
 LDCM0444  CL53 HEK-293T C122(0.80)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C122(1.15)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C122(0.99)  LDD1649  [5]
 LDCM0451  CL6 HEK-293T C122(1.16)  LDD1654  [5]
 LDCM0454  CL62 HEK-293T C122(0.99)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C122(0.88)  LDD1658  [5]
 LDCM0457  CL65 HEK-293T C122(0.88)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C122(1.29)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C122(1.13)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C122(1.13)  LDD1665  [5]
 LDCM0467  CL74 HEK-293T C122(1.17)  LDD1670  [5]
 LDCM0470  CL77 HEK-293T C122(0.84)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C122(1.15)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C122(1.07)  LDD1675  [5]
 LDCM0480  CL86 HEK-293T C122(0.99)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C122(0.88)  LDD1684  [5]
 LDCM0483  CL89 HEK-293T C122(0.98)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C122(1.01)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C122(1.03)  LDD1689  [5]
 LDCM0493  CL98 HEK-293T C122(0.98)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C122(1.05)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C122(0.92)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C122(0.83)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C122(1.04)  LDD1631  [5]
 LDCM0022  KB02 A2780 C141(2.34)  LDD2254  [2]
 LDCM0023  KB03 A2780 C141(2.59)  LDD2671  [2]
 LDCM0024  KB05 MEL167 C141(2.05)  LDD3316  [2]
 LDCM0109  NEM HeLa N.A.  LDD0225  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alfacalcidol Small molecular drug DB01436
Calcitriol Small molecular drug DB00136
Cholecalciferol Small molecular drug DB00169
Ergocalciferol Small molecular drug DB00153
Oleic Acid Small molecular drug DB04224
Vitamin D . DB11094

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402