Details of the Target

General Information of Target

Target ID LDTP01949
Target Name C-reactive protein (CRP)
Gene Name CRP
Gene ID 1401
Synonyms
PTX1; C-reactive protein [Cleaved into: C-reactive protein(1-205)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEKLLCFLVLTSLSHAFGQTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTE
LSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWES
ASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMW
DFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
Target Type
Clinical trial
Target Bioclass
Other
Family
Pentraxin family
Subcellular location
Secreted
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
TTD ID
T52953
Uniprot ID
P02741
DrugMap ID
TTG01U6
Ensemble ID
ENST00000255030.9
HGNC ID
HGNC:2367

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DANG SNV: p.S33L .
HCC15 SNV: p.P47A .
JURKAT SNV: p.S92I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K25(4.95)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270