Details of the Target

General Information of Target

Target ID LDTP01937
Target Name Apolipoprotein A-II (APOA2)
Gene Name APOA2
Gene ID 336
Synonyms
Apolipoprotein A-II; Apo-AII; ApoA-II; Apolipoprotein A2) [Cleaved into: Proapolipoprotein A-II; ProapoA-II; Truncated apolipoprotein A-II; Apolipoprotein A-II(1-76))]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLLAATVLLLTICSLEGALVRRQAKEPCVESLVSQYFQTVTDYGKDLMEKVKSPELQAE
AKSYFEKSKEQLTPLIKKAGTELVNFLSYFVELGTQPATQ
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Apolipoprotein A2 family
Subcellular location
Secreted
Function May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.
TTD ID
T75655
Uniprot ID
P02652
DrugMap ID
TTGQA9W
Ensemble ID
ENST00000367990.7
HGNC ID
HGNC:601

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity cationic amino acid transporter 1 (SLC7A1) Cationic amino acid transporter (CAT) (TC 2.A.3.3) family P30825
Stomatin (STOM) Band 7/mec-2 family P27105
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Gap junction alpha-8 protein (GJA8) Connexin family P48165
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Pannexin-1 (PANX1) Pannexin family Q96RD7
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Transmembrane protein 45A (TMEM45A) TMEM45 family Q9NWC5
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Infigratinib Small molecular drug DB11886
Sirolimus Small molecular drug DB00877
Copper . DB09130
Zinc . DB01593
Zinc Acetate . DB14487
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
B-octylglucoside Small molecular drug D02UVH

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.