Details of the Target

General Information of Target

Target ID LDTP01926
Target Name Collagen alpha-1(III) chain (COL3A1)
Gene Name COL3A1
Gene ID 1281
Synonyms
Collagen alpha-1(III) chain
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMSFVQKGSWLLLALLHPTIILAQQEAVEGGCSHLGQSYADRDVWKPEPCQICVCDSGSV
LCDDIICDDQELDCPNPEIPFGECCAVCPQPPTAPTRPPNGQGPQGPKGDPGPPGIPGRN
GDPGIPGQPGSPGSPGPPGICESCPTGPQNYSPQYDSYDVKSGVAVGGLAGYPGPAGPPG
PPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGPPGPPGAIGPSGPAGKDGESGRPGRPG
ERGLPGPPGIKGPAGIPGFPGMKGHRGFDGRNGEKGETGAPGLKGENGLPGENGAPGPMG
PRGAPGERGRPGLPGAAGARGNDGARGSDGQPGPPGPPGTAGFPGSPGAKGEVGPAGSPG
SNGAPGQRGEPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGAPGLMGARGPPGPAG
ANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPG
AAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEPGRDGVPGGPGMRGMPG
SPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPG
GPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQGLQGLPGTGGPPGENGKPGEPG
PKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPPGAAG
TPGLQGMPGERGGLGSPGPKGDKGEPGGPGADGVPGKDGPRGPTGPIGPPGPAGQPGDKG
EGGAPGLPGIAGPRGSPGERGETGPPGPAGFPGAPGQNGEPGGKGERGAPGEKGEGGPPG
VAGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLPGPPGSNGNPGPPGPSGSPG
KDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAG
PPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDG
LPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAG
SRGAPGPQGPRGDKGETGERGAAGIKGHRGFPGNPGAPGSPGPAGQQGAIGSPGPAGPRG
PVGPSGPPGKDGTSGHPGPIGPPGPRGNRGERGSEGSPGHPGQPGPPGPPGAPGPCCGGV
GAAAIAGIGGEKAGGFAPYYGDEPMDFKINTDEIMTSLKSVNGQIESLISPDGSRKNPAR
NCRDLKFCHPELKSGEYWVDPNQGCKLDAIKVFCNMETGETCISANPLNVPRKHWWTDSS
AEKKHVWFGESMDGGFQFSYGNPELPEDVLDVHLAFLRLLSSRASQNITYHCKNSIAYMD
QASGNVKKALKLMGSNEGEFKAEGNSKFTYTVLEDGCTKHTGEWSKTVFEYRTRKAVRLP
IVDIAPYDIGGPDQEFGVDVGPVCFL
Target Bioclass
Other
Family
Fibrillar collagen family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Uniprot ID
P02461
Ensemble ID
ENST00000304636.9
HGNC ID
HGNC:2201
ChEMBL ID
CHEMBL2364188

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.P126T .
BT549 SNV: p.D1093Y .
CCLP1 SNV: p.L409V .
COLO679 SNV: p.G1173E .
DU145 SNV: p.R368I .
HCC15 SNV: p.P581H .
HCT116 SNV: p.E682D .
HCT15 SNV: p.G552E .
HUPT3 SNV: p.G1050D .
IGR1 SNV: p.G1014E .
IGR37 SNV: p.P895S .
IGR39 SNV: p.P895S .
KYSE150 SNV: p.D64H .
LNCaP clone FGC SNV: p.P178H .
MCC13 SNV: p.P425S; p.D467N; p.R761K DBIA    Probe Info 
MCC26 SNV: p.G636R;p.G748A
Substitution: p.P1186F		 DBIA    Probe Info 
MELHO SNV: p.P700L .
MEWO SNV: p.D156N .
MFE319 Insertion: p.G139WfsTer4
SNV: p.P1193L		 .
NCIH1048 SNV: p.M1332I .
NCIH1299 Deletion: p.P245LfsTer18 .
NCIH1666 SNV: p.P443A .
NCIH1793 SNV: p.Q149H .
NCIH1944 SNV: p.P553T .
NCIH196 SNV: p.G420C DBIA    Probe Info 
NCIH2172 SNV: p.P182T; p.C1464R .
NCIH2286 SNV: p.P571H; p.G576C; p.K779R .
NCIH23 SNV: p.G924C .
SNU869 SNV: p.Q102L .
SW480 SNV: p.R1432Ter .
SW948 SNV: p.P533Q .
TE4 SNV: p.M299I .
TOV21G SNV: p.P830R .
WM793 SNV: p.G318D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1417(1.68)  LDD3323  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0022  KB02 CAL-78 C1417(1.57)  LDD2291  [1]
 LDCM0023  KB03 CAL-78 C1417(1.96)  LDD2708  [1]
 LDCM0024  KB05 SKMEL24 C1417(1.68)  LDD3323  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SPARC (SPARC) SPARC family P09486
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like protein 12 (KLHL12) . Q53G59

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Collagenase Clostridium Histolyticum BiotechDrug DB00048

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.