Details of the Target

General Information of Target

Target ID	LDTP01866
Target Name	Interferon alpha-5 (IFNA5)
Gene Name	IFNA5
Gene ID	3442
Synonyms	Interferon alpha-5; IFN-alpha-5; Interferon alpha-61; Interferon alpha-G; LeIF G
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MALPFVLLMALVVLNCKSICSLGCDLPQTHSLSNRRTLMIMAQMGRISPFSCLKDRHDFG FPQEEFDGNQFQKAQAISVLHEMIQQTFNLFSTKDSSATWDETLLDKFYTELYQQLNDLE ACMMQEVGVEDTPLMNVDSILTVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSFSLSAN LQERLRRKE
Target Type	Clinical trial
Target Bioclass	Cytokine and receptor
Family	Alpha/beta interferon family
Subcellular location	Secreted
Function	Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
TTD ID	T08156
Uniprot ID	P01569
DrugMap ID	TTLHGSF
Ensemble ID	ENST00000610521.2
HGNC ID	HGNC:5426
ChEMBL ID	CHEMBL3856161

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
ATP probe Probe Info			N.A.	LDD0199	[1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 2

Click To Hide/Show 2 Drug(s) Interacting with This Target

Drug Name				Drug Type	External ID
Interferon Alpha 5				.	D0E1FP
Nahe-001				.	D0F2WN

References

1	Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.