Details of the Target

General Information of Target

Target ID LDTP01839
Target Name Proenkephalin-A (PENK)
Gene Name PENK
Gene ID 5179
Synonyms
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin; Opioid growth factor; OGF; PENK(114-133; PENK(143-183; Met-enkephalin-Arg-Gly-Leu; Leu-enkephalin; PENK(237-258; Met-enkephalin-Arg-Phe]
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLK
IWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPM
EPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEE
EVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEA
LPSDEEGESYSKEVPEMEKRYGGFMRF
Target Bioclass
Transporter and channel
Family
Opioid neuropeptide precursor family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen
Function
[Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.; [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release.; [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum.; [PENK(237-258)]: Increases glutamate release in the striatum.
Uniprot ID
P01210
Ensemble ID
ENST00000314922.3
HGNC ID
HGNC:8831

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K259(1.27)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270