Details of the Target

General Information of Target

Target ID LDTP01838
Target Name Pro-opiomelanocortin (POMC)
Gene Name POMC
Gene ID 5443
Synonyms
Pro-opiomelanocortin; POMC; Corticotropin-lipotropin) [Cleaved into: NPP; Melanotropin gamma; Gamma-MSH; Potential peptide; Corticotropin; Adrenocorticotropic hormone; ACTH; Melanocyte-stimulating hormone alpha; Alpha-MSH; Melanotropin alpha; Corticotropin-like intermediary peptide; CLIP; Lipotropin beta; Beta-LPH; Lipotropin gamma; Gamma-LPH; Melanocyte-stimulating hormone beta; Beta-MSH; Melanotropin beta; Beta-endorphin; Met-enkephalin]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPRSCCSRSGALLLALLLQASMEVRGWCLESSQCQDLTTESNLLECIRACKPDLSAETPM
FPGNGDEQPLTENPRKYVMGHFRWDRFGRRNSSSSGSSGAGQKREDVSAGEDCGPLPEGG
PEPRSDGAKPGPREGKRSYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEFKREL
TGQRLREGDGPDGPADDGAGAQADLEHSLLVAAEKKDEGPYRMEHFRWGSPPKDKRYGGF
MTSEKSQTPLVTLFKNAIIKNAYKKGE
Target Type
Literature-reported
Target Bioclass
Other
Family
POMC family
Subcellular location
Secreted
Function
[Corticotropin]: Stimulates the adrenal glands to release cortisol.; [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes.; [Beta-endorphin]: Endogenous orexigenic opiate.; [Met-enkephalin]: Endogenous opiate.
TTD ID
T62912
Uniprot ID
P01189
DrugMap ID
TT21AKM
Ensemble ID
ENST00000264708.7
HGNC ID
HGNC:9201

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
5'-deoxynucleotidase HDDC2 (HDDC2) HDDC2 family Q7Z4H3
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
V-type proton ATPase subunit d 2 (ATP6V0D2) V-ATPase V0D/AC39 subunit family Q8N8Y2
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Sulfite oxidase, mitochondrial (SUOX) . P51687
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
Class A basic helix-loop-helix protein 9 (BHLHA9) . Q7RTU4
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
Coiled-coil domain-containing protein 102B (CCDC102B) . Q68D86
Heat shock factor 2-binding protein (HSF2BP) . O75031
Kelch-like protein 42 (KLHL42) . Q9P2K6

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Loperamide Small molecular drug DB00836
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dihydromorphine Small molecular drug D0B7GU
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Etorphine Small molecular drug DB01497

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.