Details of the Target

General Information of Target

Target ID LDTP01796
Target Name Complement factor D (CFD)
Gene Name CFD
Gene ID 1675
Synonyms
DF; PFD; Complement factor D; EC 3.4.21.46; Adipsin; C3 convertase activator; Properdin factor D
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL
SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN
RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR
VASYAAWIDSVLA
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
TTD ID
T66383
Uniprot ID
P00746
DrugMap ID
TT8D13I
Ensemble ID
ENST00000327726.11
HGNC ID
HGNC:2771
ChEMBL ID
CHEMBL2176771

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0447  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lampalizumab Antibody DM7Z6Y
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-factor D Antibody D08ZDI
Ach-4471 . D0C9MA
Investigative
Click To Hide/Show 4 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
34-dichloroisocoumarin Small molecular drug DB04459
Example 373 [Wo2012093101] Small molecular drug D04MIN
2-aminobenzyl Alcohol . DB03058
Hc3-1496 . D0P8LR

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.