Details of the Target

General Information of Target

Target ID LDTP01793
Target Name Haptoglobin-related protein (HPR)
Gene Name HPR
Gene ID 3250
Synonyms
Haptoglobin-related protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDLGAVISLLLWGRQLFALYSGNDVTDISDDRFPKPPEIANGYVEHLFRYQCKNYYRLR
TEGDGVYTLNDKKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAK
MVSHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVL
HPNYHQVDIGLIKLKQKVLVNERVMPICLPSKNYAEVGRVGYVSGWGQSDNFKLTDHLKY
VMLPVADQYDCITHYEGSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSA
FAVHDLEEDTWYAAGILSFDKSCAVAEYGVYVKVTSIQHWVQKTIAEN
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function
Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Uniprot ID
P00739
Ensemble ID
ENST00000540303.7
HGNC ID
HGNC:5156

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT SNV: p.K169E .
HT3 SNV: p.F34L .
HUPT4 Substitution: p.H185S .
JHH6 Substitution: p.L199S .
JHH7 Substitution: p.H185S .
KP4 Substitution: p.L199S .
NALM6 SNV: p.A324T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C266(1.79)  LDD3360  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hep 3B2.1-7 C266(1.49)  LDD2353  [1]
 LDCM0023  KB03 Hep 3B2.1-7 C266(1.66)  LDD2770  [1]
 LDCM0024  KB05 NCI-H3122 C266(1.79)  LDD3360  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840