Details of the Target

General Information of Target

Target ID LDTP01791
Target Name Complement C1r subcomponent (C1R)
Gene Name C1R
Gene ID 715
Synonyms
Complement C1r subcomponent; EC 3.4.21.41; Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWLLYLLVPALFCRAGGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVF
QQFDLEPSEGCFYDYVKISADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDF
SNEENGTIMFYKGFLAYYQAVDLDECASRSKSGEEDPQPQCQHLCHNYVGGYFCSCRPGY
ELQEDTHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF
DIDDHQQVHCPYDQLQIYANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKL
RYTTEIIKCPQPKTLDEFTIIQNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQD
DGTWHRAMPRCKIKDCGQPRNLPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSR
ESEQGVYTCTAQGIWKNEQKGEKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVF
TNIHGRGGGALLGDRWILTAAHTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIRRV
SVHPDYRQDESYNFEGDIALLELENSVTLGPNLLPICLPDNDTFYDLGLMGYVSGFGVME
EKIAHDLRFVRLPVANPQACENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAV
RDPNTDRWVATGIVSWGIGCSRGYGFYTKVLNYVDWIKKEMEEED
Target Bioclass
Enzyme
Family
Peptidase S1 family
Subcellular location
Secreted
Function C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
Uniprot ID
P00736
HGNC ID
HGNC:1246
ChEMBL ID
CHEMBL4611

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C338(2.91)  LDD3314  [1]
Acrolein
 Probe Info  		N.A.  LDD0233  [2]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C451(0.96)  LDD1507  [3]
 LDCM0276  AC17 HEK-293T C451(0.79)  LDD1515  [3]
 LDCM0285  AC25 HEK-293T C451(1.17)  LDD1524  [3]
 LDCM0294  AC33 HEK-293T C451(1.11)  LDD1533  [3]
 LDCM0303  AC41 HEK-293T C451(1.11)  LDD1542  [3]
 LDCM0311  AC49 HEK-293T C451(1.27)  LDD1550  [3]
 LDCM0320  AC57 HEK-293T C451(1.32)  LDD1559  [3]
 LDCM0356  AKOS034007680 HEK-293T C451(0.98)  LDD1570  [3]
 LDCM0404  CL17 HEK-293T C451(0.93)  LDD1608  [3]
 LDCM0417  CL29 HEK-293T C451(0.91)  LDD1621  [3]
 LDCM0431  CL41 HEK-293T C451(1.13)  LDD1635  [3]
 LDCM0440  CL5 HEK-293T C451(1.21)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C451(1.03)  LDD1647  [3]
 LDCM0457  CL65 HEK-293T C451(1.22)  LDD1660  [3]
 LDCM0470  CL77 HEK-293T C451(1.14)  LDD1673  [3]
 LDCM0483  CL89 HEK-293T C451(0.92)  LDD1686  [3]
 LDCM0022  KB02 HG-3 C268(2.77)  LDD2355  [1]
 LDCM0023  KB03 HG-3 C268(3.95)  LDD2772  [1]
 LDCM0024  KB05 IGR37 C338(2.91)  LDD3314  [1]
 LDCM0109  NEM HeLa N.A.  LDD0233  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complement C1r subcomponent (C1R) Peptidase S1 family P00736
Complement C1s subcomponent (C1S) Peptidase S1 family P09871
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Plasma protease C1 inhibitor (SERPING1) Serpin family P05155

The Drug(s) Related To This Target

Approved
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Human C1-esterase Inhibitor BiotechDrug DB06404
Palivizumab Monoclonal antibody DB00110
Conestat Alfa . DB09228
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Daclizumab Monoclonal antibody DB00111
Gabexate Small molecular drug DB12831

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402