Details of the Target

General Information of Target

Target ID LDTP01765
Target Name Alcohol dehydrogenase 1C (ADH1C)
Gene Name ADH1C
Gene ID 126
Synonyms
ADH3; Alcohol dehydrogenase 1C; EC 1.1.1.1; Alcohol dehydrogenase subunit gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTAGKVIKCKAAVLWELKKPFSIEEVEVAPPKAHEVRIKMVAAGICRSDEHVVSGNLVT
PLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRICKNPESNYCLKNDLGNP
RGTLQDGTRRFTCSGKPIHHFVGVSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTG
YGSAVKVAKVTPGSTCAVFGLGGVGLSVVMGCKAAGAARIIAVDINKDKFAKAKELGATE
CINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPDSQ
NLSINPMLLLTGRTWKGAIFGGFKSKESVPKLVADFMAKKFSLDALITNILPFEKINEGF
DLLRSGKSIRTVLTF
Target Bioclass
Enzyme
Family
Zinc-containing alcohol dehydrogenase family
Subcellular location
Cytoplasm
Function Alcohol dehydrogenase. Exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism.
Uniprot ID
P00326
Ensemble ID
ENST00000515683.6
HGNC ID
HGNC:251
ChEMBL ID
CHEMBL3285

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C47(1.68)  LDD3327  [1]
BTD
 Probe Info  		C98(0.55)  LDD2141  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BxPC-3 C98(1.10)  LDD2280  [1]
 LDCM0023  KB03 CFPAC-1 C98(1.58)  LDD2717  [1]
 LDCM0024  KB05 WM115 C47(1.68)  LDD3327  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C98(0.55)  LDD2141  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761