Details of the Target

General Information of Target

Target ID LDTP01753
Target Name Dynein axonemal light chain 4 (DNAL4)
Gene Name DNAL4
Gene ID 10126
Synonyms
Dynein axonemal light chain 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGETEGKKDEADYKRLQTFPLVRHSDMPEEMRVETMELCVTACEKFSNNNESAAKMIKET
MDKKFGSSWHVVIGEGFGFEITHEVKNLLYLYFGGTLAVCVWKCS
Target Bioclass
Other
Family
Dynein light chain family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity.
Uniprot ID
O96015
Ensemble ID
ENST00000216068.9
HGNC ID
HGNC:2955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0176  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Uridine diphosphate glucose pyrophosphatase NUDT22 (NUDT22) Nudix hydrolase family Q9BRQ3
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) CAMK Ser/Thr protein kinase family Q13557
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Other
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich hydrophobic domain-containing protein 2 (CHIC2) CHIC family Q9UKJ5
Dynein axonemal light chain 4 (DNAL4) Dynein light chain family O96015
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
Dynein light chain 2, cytoplasmic (DYNLL2) Dynein light chain family Q96FJ2
Guanine nucleotide-binding protein subunit alpha-14 (GNA14) G-alpha family O95837
Keratin-associated protein 12-3 (KRTAP12-3) KRTAP type 12 family P60328
Keratin-associated protein 9-8 (KRTAP9-8) KRTAP type 9 family Q9BYQ0
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Four and a half LIM domains protein 5 (FHL5) . Q5TD97

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060