Details of the Target

General Information of Target

Target ID LDTP01752
Target Name Protein Wnt-11 (WNT11)
Gene Name WNT11
Gene ID 7481
Synonyms
Protein Wnt-11
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRARPQVCEALLFALALQTGVCYGIKWLALSKTPSALALNQTQHCKQLEGLVSAQVQLCR
SNLELMHTVVHAAREVMKACRRAFADMRWNCSSIELAPNYLLDLERGTRESAFVYALSAA
AISHAIARACTSGDLPGCSCGPVPGEPPGPGNRWGGCADNLSYGLLMGAKFSDAPMKVKK
TGSQANKLMRLHNSEVGRQALRASLEMKCKCHGVSGSCSIRTCWKGLQELQDVAADLKTR
YLSATKVVHRPMGTRKHLVPKDLDIRPVKDSELVYLQSSPDFCMKNEKVGSHGTQDRQCN
KTSNGSDSCDLMCCGRGYNPYTDRVVERCHCKYHWCCYVTCRRCERTVERYVCK
Target Bioclass
Other
Family
Wnt family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Uniprot ID
O96014
Ensemble ID
ENST00000322563.8
HGNC ID
HGNC:12776

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C157(3.31)  LDD3364  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0371  CL102 HEK-293T C157(0.96)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C157(0.96)  LDD1576  [2]
 LDCM0375  CL106 HEK-293T C157(1.03)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C157(0.76)  LDD1580  [2]
 LDCM0380  CL110 HEK-293T C157(1.17)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C157(0.79)  LDD1585  [2]
 LDCM0384  CL114 HEK-293T C157(1.29)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C157(0.89)  LDD1589  [2]
 LDCM0388  CL118 HEK-293T C157(0.99)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C157(0.95)  LDD1593  [2]
 LDCM0393  CL122 HEK-293T C157(0.95)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C157(0.88)  LDD1598  [2]
 LDCM0397  CL126 HEK-293T C157(1.28)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C157(1.21)  LDD1602  [2]
 LDCM0401  CL14 HEK-293T C157(1.15)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C157(0.91)  LDD1606  [2]
 LDCM0407  CL2 HEK-293T C157(1.15)  LDD1611  [2]
 LDCM0414  CL26 HEK-293T C157(1.04)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C157(0.93)  LDD1619  [2]
 LDCM0418  CL3 HEK-293T C157(0.74)  LDD1622  [2]
 LDCM0428  CL39 HEK-293T C157(1.05)  LDD1632  [2]
 LDCM0441  CL50 HEK-293T C157(1.04)  LDD1645  [2]
 LDCM0454  CL62 HEK-293T C157(1.03)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C157(0.89)  LDD1658  [2]
 LDCM0467  CL74 HEK-293T C157(1.04)  LDD1670  [2]
 LDCM0480  CL86 HEK-293T C157(1.27)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C157(0.89)  LDD1684  [2]
 LDCM0493  CL98 HEK-293T C157(1.19)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C157(0.95)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C157(0.85)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C157(0.91)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C157(1.14)  LDD1631  [2]
 LDCM0022  KB02 COLO 320 C157(1.45)  LDD2303  [1]
 LDCM0023  KB03 DAN-G C283(1.62); C157(1.63)  LDD2730  [1]
 LDCM0024  KB05 NCI-N87 C157(3.31)  LDD3364  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402