Details of the Target

General Information of Target

Target ID LDTP01749
Target Name Napsin-A (NAPSA)
Gene Name NAPSA
Gene ID 9476
Synonyms
NAP1; NAPA; Napsin-A; EC 3.4.23.-; Aspartyl protease 4; ASP4; Asp 4; Napsin-1; TA01/TA02
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPPPLLQPLLLLLPLLNVEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPS
PGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHH
RFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAF
AHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDP
AHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALH
AAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVIQTTRNGVRLCLSGFQA
LDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARARTRGADLGWGETAQAQFPG
Target Bioclass
Enzyme
Family
Peptidase A1 family
Subcellular location
Secreted
Function May be involved in processing of pneumocyte surfactant precursors.
Uniprot ID
O96009
Ensemble ID
ENST00000253719.7
HGNC ID
HGNC:13395

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C215(1.74); C274(1.44)  LDD3311  [1]
NAIA_5
 Probe Info  		C84(0.00); C42(0.00)  LDD2224  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C103(1.64); C66(1.12)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C103(2.35); C66(1.24)  LDD2660  [1]
 LDCM0024  KB05 G361 C215(1.74); C274(1.44)  LDD3311  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264