Details of the Target

General Information of Target

Target ID LDTP01723
Target Name Formimidoyltransferase-cyclodeaminase (FTCD)
Gene Name FTCD
Gene ID 10841
Synonyms
Formimidoyltransferase-cyclodeaminase; Formiminotransferase-cyclodeaminase; FTCD; LCHC1) [Includes: Glutamate formimidoyltransferase; EC 2.1.2.5; Glutamate formiminotransferase; Glutamate formyltransferase; Formimidoyltetrahydrofolate cyclodeaminase; EC 4.3.1.4; Formiminotetrahydrofolate cyclodeaminase)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVE
GALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELD
VPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARK
FLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLD
FEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRI
RLVVSRLGLDSLCPFSPKERIIEYLVPERGPERGLGSKSLRAFVGEVGARSAAPGGGSVA
AAAAAMGAALGSMVGLMTYGRRQFQSLDTTMRRLIPPFREASAKLTTLVDADAEAFTAYL
EAMRLPKNTPEEKDRRTAALQEGLRRAVSVPLTLAETVASLWPALQELARCGNLACRSDL
QVAAKALEMGVFGAYFNVLINLRDITDEAFKDQIHHRVSSLLQEAKTQAALVLDCLETRQ
E
Target Bioclass
Enzyme
Family
Cyclodeaminase/cyclohydrolase family; Formiminotransferase family
Subcellular location
Cytoplasm, cytosol
Function
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.; Binds and promotes bundling of vimentin filaments originating from the Golgi.
Uniprot ID
O95954
Ensemble ID
ENST00000291670.9
HGNC ID
HGNC:3974

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 SNV: p.G80V .
DU145 SNV: p.F241V .
JEKO1 SNV: p.L461R .
JURLMK1 SNV: p.T244A .
MCC13 Substitution: p.R208C .
MDAMB157 SNV: p.K210M .
MFE319 SNV: p.E117G .
MOLM16 SNV: p.A352E .
MOLT4 Deletion: p.A62PfsTer7
SNV: p.G61R		 .
RH30 SNV: p.N473T .
SNGM SNV: p.A364V .
U937 SNV: p.P164L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C57(0.00); C313(0.00); C91(0.00); C286(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C313(2.56); C535(2.58); C57(2.13)  LDD3424  [2]
1c-yne
 Probe Info  		N.A.  LDD0228  [3]
W1
 Probe Info  		C313(0.00); C57(0.00)  LDD0236  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hep 3B2.1-7 C313(1.32); C535(1.61)  LDD2353  [2]
 LDCM0023  KB03 Hep 3B2.1-7 C313(1.83); C535(1.71)  LDD2770  [2]
 LDCM0024  KB05 SK-HEP1 C313(2.56); C535(2.58); C57(2.13)  LDD3424  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein PALS1 (PALS1) MAGUK family Q8N3R9
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Protein KASH5 (KASH5) . Q8N6L0

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Glutamic Acid Small molecular drug DB00142
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tetrahydrofolic Acid Small molecular drug DB00116
(6r)-folinic Acid . DB03256

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.