Details of the Target

General Information of Target

Target ID LDTP01721
Target Name T-box transcription factor TBX6 (TBX6)
Gene Name TBX6
Gene ID 6911
Synonyms
T-box transcription factor TBX6; T-box protein 6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYHPRELYPSLGAGYRLGPAQPGADSSFPPALAEGYRYPELDTPKLDCFLSGMEAAPRTL
AAHPPLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRM
FPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPA
TGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFR
FPETTFISVTAYQNPQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEA
YGSGDTPGGPCDSTLGGDIRESDPEQAPAPGEATAAPAPLCGGPSAEAYLLHPAAFHGAP
SHLPTRSPSFPEAPDSGRSAPYSAAFLELPHGSGGSGYPAAPPAVPFAPHFLQGGPFPLP
YTAPGGYLDVGSKPMY
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia.
Uniprot ID
O95947
Ensemble ID
ENST00000279386.6
HGNC ID
HGNC:11605

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.M120I .
CCK81 SNV: p.A55G .
HUH7 SNV: p.P189A .
JURKAT Deletion: p.A13PfsTer20
SNV: p.R37H;p.R285C		 .
LNCaP clone FGC Insertion: p.L41TfsTer5 .
MFE319 SNV: p.P204L .
MOLT4 SNV: p.A401V .
NUGC3 Insertion: p.M236HfsTer44 .
SNU5 SNV: p.P189A .
SW1116 SNV: p.P189A .
TOV21G SNV: p.P409Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C124(1.02)  LDD1702  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C124(1.02)  LDD1702  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761