Details of the Target

General Information of Target

Target ID LDTP01715
Target Name Pre-mRNA-splicing factor SYF2 (SYF2)
Gene Name SYF2
Gene ID 25949
Synonyms
CBPIN; GCIPIP; Pre-mRNA-splicing factor SYF2; CCNDBP1-interactor; p29
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDK
RLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNP
DLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEID
RMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERG
TAV
Target Bioclass
Other
Family
SYF2 family
Subcellular location
Nucleus
Function Involved in pre-mRNA splicing as component of the spliceosome.
Uniprot ID
O95926
Ensemble ID
ENST00000236273.9
HGNC ID
HGNC:19824

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NALM6 Insertion: p.A73SfsTer24 .
SNGM Insertion: p.A73SfsTer24 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C88(0.62)  LDD2092  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
ATP probe
 Probe Info  		N.A.  LDD0199  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C88(0.94)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C88(0.91)  LDD2112  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C88(0.62)  LDD2092  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C88(0.77)  LDD2104  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C88(0.96)  LDD2108  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C88(1.14)  LDD2114  [1]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C88(0.94)  LDD2116  [1]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C88(1.07)  LDD2149  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.