Details of the Target
General Information of Target
| Target ID | LDTP01694 | |||||
|---|---|---|---|---|---|---|
| Target Name | Uridine diphosphate glucose pyrophosphatase NUDT14 (NUDT14) | |||||
| Gene Name | NUDT14 | |||||
| Gene ID | 256281 | |||||
| Synonyms |
UGPP; Uridine diphosphate glucose pyrophosphatase NUDT14; UDPG pyrophosphatase; UGPPase; EC 3.6.1.45; Nucleoside diphosphate-linked moiety X motif 14; Nudix motif 14 |
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| 3D Structure | ||||||
| Sequence |
MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQ
FRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVAC KEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIE VVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPNLDLQ |
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| Target Bioclass |
Enzyme
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| Family |
Nudix hydrolase family
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| Subcellular location |
Cytoplasm
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| Function |
Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K59(1.32) | LDD0277 | [1] | |
|
DBIA Probe Info |
 |
C12(2.11) | LDD3345 | [2] | |
|
IA-alkyne Probe Info |
 |
N.A. | LDD0036 | [3] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2223 | [4] | |
Competitor(s) Related to This Target
References