Details of the Target

General Information of Target

Target ID LDTP01693
Target Name Guanylyl cyclase-activating protein 3 (GUCA1C)
Gene Name GUCA1C
Gene ID 9626
Synonyms
GCAP3; Guanylyl cyclase-activating protein 3; GCAP 3; Guanylate cyclase activator 1C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQV
YNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAV
QALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLR
VICNGKQPDMETDSSKSPDKAGLGKVKMK
Target Bioclass
Other
Function
Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.
Uniprot ID
O95843
Ensemble ID
ENST00000261047.8
HGNC ID
HGNC:4680

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8305C SNV: p.D58Y .
MEWO SNV: p.D69N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C183(0.88)  LDD3370  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 K052 C183(0.72)  LDD2427  [1]
 LDCM0023  KB03 K052 C183(0.75)  LDD2844  [1]
 LDCM0024  KB05 OCI-AML-2 C183(0.88)  LDD3370  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840