Details of the Target

General Information of Target

Target ID LDTP01681
Target Name Caveolae-associated protein 2 (CAVIN2)
Gene Name CAVIN2
Gene ID 8436
Synonyms
SDPR; Caveolae-associated protein 2; Cavin-2; PS-p68; Phosphatidylserine-binding protein; Serum deprivation-response protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLT
LLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRK
VSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAV
EGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVD
SLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRK
KVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKAT
SRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQ
VHQTS
Target Bioclass
Other
Family
CAVIN family
Subcellular location
Cytoplasm, cytosol
Function
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae.
Uniprot ID
O95810
Ensemble ID
ENST00000304141.5
HGNC ID
HGNC:10690

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K102(0.60); K113(10.00); K140(5.15); K238(10.00)  LDD0277  [1]
DBIA
 Probe Info  		C136(2.08)  LDD3314  [2]
BTD
 Probe Info  		C136(0.61)  LDD2109  [3]
IPM
 Probe Info  		C136(0.98)  LDD1701  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C136(0.77)  LDD1702  [3]
 LDCM0022  KB02 A-172 C136(2.45)  LDD2251  [2]
 LDCM0023  KB03 MDA-MB-231 C136(0.98)  LDD1701  [3]
 LDCM0024  KB05 IGR37 C136(2.08)  LDD3314  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C136(0.61)  LDD2109  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C136(0.61)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C136(0.73)  LDD2125  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C136(0.87)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C136(0.69)  LDD2140  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolin-1 (CAV1) Caveolin family Q03135
Pleckstrin homology domain-containing family F member 1 (PLEKHF1) . Q96S99
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caveolae-associated protein 1 (CAVIN1) CAVIN family Q6NZI2
Microspherule protein 1 (MCRS1) . Q96EZ8
Pleckstrin (PLEK) . P08567

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764