Details of the Target

General Information of Target

Target ID LDTP01648
Target Name Endothelin-converting enzyme-like 1 (ECEL1)
Gene Name ECEL1
Gene ID 9427
Synonyms
XCE; Endothelin-converting enzyme-like 1; EC 3.4.24.-; Xce protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPPYSLTAHYDEFQEVKYVSRCGAGGARGASLPPGFPLGAARSATGARSGLPRWNRREV
CLLSGLVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASI
DPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKV
RAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGVYS
AAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSL
LGADAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLL
DQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREA
LHELAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYI
LGQRLEELDWMDAETRAAARAKLQYMMVMVGYPDFLLKPDAVDKEYEFEVHEKTYFKNIL
NSIRFSIQLSVKKIRQEVDKSTWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQS
LNYGGIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVY
NQRVNGKHTLGENIADMGGLKLAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWC
IKRRSQSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW
Target Bioclass
Enzyme
Family
Peptidase M13 family
Subcellular location
Membrane
Function May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.
Uniprot ID
O95672
Ensemble ID
ENST00000304546.6
HGNC ID
HGNC:3147

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.L680F .
AN3CA SNV: p.G93S .
HCT116 Deletion: p.H353TfsTer8 .
HEC1 SNV: p.F657V .
HGC27 SNV: p.V67G .
IGROV1 SNV: p.A106T .
IPC298 SNV: p.R756Q .
Ishikawa (Heraklio) 02 ER SNV: p.R29C .
MFE319 SNV: p.A28T .
OCUG1 SNV: p.S44R; p.G666R .
RKO SNV: p.Y11C .
SF295 SNV: p.W358L .
SKNSH SNV: p.G26V; p.G679C .
TOV21G SNV: p.P200H; p.Y684H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C441(5.76)  LDD3356  [1]
TFBX
 Probe Info  		C23(0.00); C649(0.00); C441(0.00)  LDD0148  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 NCI-H2172 C441(2.77)  LDD2522  [1]
 LDCM0023  KB03 NCI-H2172 C441(5.39)  LDD2939  [1]
 LDCM0024  KB05 NCI-H2172 C441(5.76)  LDD3356  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255