Details of the Target
General Information of Target
| Target ID | LDTP01643 | |||||
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| Target Name | Follistatin-related protein 3 (FSTL3) |
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| Gene Name | FSTL3 | |||||
| Gene ID | 10272 | |||||
| Synonyms |
FLRG; Follistatin-related protein 3; Follistatin-like protein 3; Follistatin-related gene protein |
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| 3D Structure | ||||||
| Sequence |
MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAE
CCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCE CAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQ SCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHA GSCAGTPEEPPGGESAEEEENFV |
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| Target Type |
Literature-reported
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| Target Bioclass |
Other
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| Subcellular location |
Secreted; Nucleus
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| Function |
Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.
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Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C229(3.23) | LDD3440 | [1] | |
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5E-2FA Probe Info |
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N.A. | LDD2235 | [2] | |
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m-APA Probe Info |
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N.A. | LDD2231 | [2] | |
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NAIA_4 Probe Info |
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N.A. | LDD2226 | [3] | |
Competitor(s) Related to This Target
References