Details of the Target

General Information of Target

Target ID LDTP01639
Target Name Adenylate cyclase type 5 (ADCY5)
Gene Name ADCY5
Gene ID 111
Synonyms
Adenylate cyclase type 5; EC 4.6.1.1; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
S
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Adenylyl cyclase class-4/guanylyl cyclase family
Subcellular location
Cell membrane
Function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion.
TTD ID
T19531
Uniprot ID
O95622
DrugMap ID
TTN64VU
Ensemble ID
ENST00000309879.9
HGNC ID
HGNC:236
ChEMBL ID
CHEMBL3189

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CHL1 SNV: p.G626S .
COLO679 SNV: p.T54I .
CORL88 SNV: p.D1047E .
HCC15 SNV: p.L937V .
HEC1 SNV: p.R512H .
IGROV1 SNV: p.M1130T .
JEKO1 SNV: p.V7M .
KMCH1 SNV: p.A60P; p.W1199R .
LS180 SNV: p.F805V .
MFE319 SNV: p.S889N .
NALM6 SNV: p.R1098W .
NCIH1155 SNV: p.S1112N .
NCIH1299 SNV: p.P679T .
NCIH196 SNV: p.K220N .
NCIH358 SNV: p.E677Ter .
SNU1 SNV: p.A499T .
SUPT1 Deletion: p.V839CfsTer129 .
TE4 SNV: p.I1110F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C64(0.25)  LDD3436  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Heraklio 02 ER- C64(2.14)  LDD2401  [1]
 LDCM0023  KB03 Heraklio 02 ER- C64(2.86)  LDD2818  [1]
 LDCM0024  KB05 SNG-M C64(0.25)  LDD3436  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840