Details of the Target

General Information of Target

Target ID	LDTP01625
Target Name	Claudin-14 (CLDN14)
Gene Name	CLDN14
Gene ID	23562
Synonyms	Claudin-14
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTG IYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAIL GGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTL LCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGYRLNDYV
Target Bioclass	Other
Family	Claudin family
Subcellular location	Cell junction, tight junction
Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Uniprot ID	O95500
Ensemble ID	ENST00000342108.2
HGNC ID	HGNC:2035

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
IA-alkyne Probe Info			N.A.	LDD0165	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Myelin and lymphocyte protein (MAL)				MAL family	P21145

Other

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Cortexin-3 (CTXN3)				Cortexin family	Q4LDR2
Plasmolipin (PLLP)				MAL family	Q9Y342

References

1	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060