Details of the Target
General Information of Target
| Target ID | LDTP01624 | |||||
|---|---|---|---|---|---|---|
| Target Name | Pantetheine hydrolase VNN2 (VNN2) | |||||
| Gene Name | VNN2 | |||||
| Gene ID | 8875 | |||||
| Synonyms |
Pantetheine hydrolase VNN2; EC 3.5.1.92; Glycosylphosphatidyl inositol-anchored protein GPI-80; Protein FOAP-4; Vascular non-inflammatory molecule 2; Vanin-2 |
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| 3D Structure | ||||||
| Sequence |
MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDI
LETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTP VQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKY HLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMN VLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLL LSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTV CQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVE TASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLF GRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML |
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| Target Bioclass |
Enzyme
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| Family |
Carbon-nitrogen hydrolase superfamily, BTD/VNN family
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| Subcellular location |
Cell membrane
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| Function |
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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BTD Probe Info |
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C415(0.93) | LDD2090 | [1] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0519 | 1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one | MDA-MB-231 | C415(0.50) | LDD2112 | [1] |
| LDCM0497 | Nucleophilic fragment 11b | MDA-MB-231 | C415(0.93) | LDD2090 | [1] |
| LDCM0512 | Nucleophilic fragment 19a | MDA-MB-231 | C415(0.92) | LDD2105 | [1] |
| LDCM0515 | Nucleophilic fragment 20b | MDA-MB-231 | C415(0.36) | LDD2108 | [1] |