Details of the Target
General Information of Target
| Target ID | LDTP01623 | |||||
|---|---|---|---|---|---|---|
| Target Name | Pantetheinase (VNN1) | |||||
| Gene Name | VNN1 | |||||
| Gene ID | 8876 | |||||
| Synonyms |
Pantetheinase; EC 3.5.1.92; Pantetheine hydrolase; Tiff66; Vascular non-inflammatory molecule 1; Vanin-1 |
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| 3D Structure | ||||||
| Sequence |
MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDIL
EGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPV QERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQN LFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMN VLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLL LSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKD LCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETAST RFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLY EKDWASNASSGLTAQARIIMLIVIAPIVCSLSW |
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| Target Bioclass |
Enzyme
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| Family |
Carbon-nitrogen hydrolase superfamily, BTD/VNN family
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| Subcellular location |
Cell membrane
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| Function | Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C411(1.35) | LDD2479 | [1] | |
Competitor(s) Related to This Target