Details of the Target
General Information of Target
| Target ID | LDTP01467 | |||||
|---|---|---|---|---|---|---|
| Target Name | Actin-binding LIM protein 3 (ABLIM3) | |||||
| Gene Name | ABLIM3 | |||||
| Gene ID | 22885 | |||||
| Synonyms |
KIAA0843; Actin-binding LIM protein 3; abLIM-3; Actin-binding LIM protein family member 3 |
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| 3D Structure | ||||||
| Sequence |
MNTSIPYQQNPYNPRGSSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSG
FFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDK VTFSGKECVCQTCSQSMASSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQT CSVILTGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCH QMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVD NEILNYKDLAALPKVKSIYEVQRPDLISYEPHSRYMSDEMLERCGYGESLGTLSPYSQDI YENLDLRQRRASSPGYIDSPTYSRQGMSPTFSRSPHHYYRSGPESGRSSPYHSQLDVRSS TPTSYQAPKHFHIPAGDSNIYRKPPIYKRHGDLSTATKSKTSEDISQTSKYSPIYSPDPY YASESEYWTYHGSPKVPRARRFSSGGEEDDFDRSMHKLQSGIGRLILKEEMKARSSSYAD PWTPPRSSTSSREALHTAGYEMSLNGSPRSHYLADSDPLISKSASLPAYRRNGLHRTPSA DLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGM TISEFDRLALWKRNELKKQARLF |
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| Target Bioclass |
Other
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| Subcellular location |
Cytoplasm
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| Function | May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| KURAMOCHI | SNV: p.M249K | . | |||
| NCIH1975 | SNV: p.S286Y | DBIA Probe Info | |||
| TE4 | SNV: p.F61I | DBIA Probe Info | |||
| U2OS | SNV: p.E617K | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
IPM Probe Info |
 |
C23(2.00) | LDD1701 | [1] | |
|
DBIA Probe Info |
 |
C178(1.01); C181(1.01); C70(0.86) | LDD0078 | [2] | |
Competitor(s) Related to This Target
References