Details of the Target

General Information of Target

Target ID LDTP01417
Target Name Contactin-5 (CNTN5)
Gene Name CNTN5
Gene ID 53942
Synonyms
Contactin-5; Neural recognition molecule NB-2; hNB-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASSWKLMLFLSVTMCLSEYSKSLPGLSTSYAALLRIKKSSSSSLFGSKTRPRYSSPSLG
TLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESVDYGPVFVQEPDDIIFPTDSDEKKVA
LNCEVRGNPVPSYRWLRNGTEIDLESDYRYSLIDGTFIISNPSEAKDSGHYQCLATNTVG
SILSREATLQFAYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVA
EDSRRFISQETGNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEP
KIEVHFPFTVTAAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQ
LDDAGIYECRAENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPT
YRWLKNGVPLSPQSRVEMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAP
TFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILN
ASKSDEGKYVCRGENVFGSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDAS
LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVS
DEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSPISSYNLQARSPFSLGWQTVK
TVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSRMIRTNEAVPKTAPTNV
SGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDES
VPPLTPFEVKVGVYNNKGDGPFSQIVVICSAEGEPSAAPTDVKATSVSVSEILVAWKHIK
ESLGRPQGFEVGYWKDMEQEDTAETVKTRGNESFVILTGLEGNTLYHFTVRAYNGAGYGP
PSSEVSATTKKSPPSQAPSNLRWEQQGSQVSLGWEPVIPLANESEVVGYKVFYRQEGHSN
SQVIETQKLQAVVPLPDAGVYIIEVRAYSEGGDGTASSQIRVPSYSGGKITSAQSTLHSL
STSSSSVTLLLALMIPSTSW
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, Contactin family
Subcellular location
Cell membrane
Function
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system.
Uniprot ID
O94779
Ensemble ID
ENST00000418526.6
HGNC ID
HGNC:2175

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.E770K .
HCT116 SNV: p.V442A .
HEC1 SNV: p.D167V .
HG3 SNV: p.S886N .
IM95 SNV: p.G315E .
IPC298 SNV: p.Q707Ter .
KARPAS422 SNV: p.G518Ter .
KMS27 SNV: p.A120P .
KYM1 SNV: p.A33S .
KYSE150 SNV: p.W5Ter .
KYSE410 SNV: p.W741G .
MCC13 SNV: p.R573K .
MELJUSO SNV: p.P307S .
MFE296 SNV: p.P283S; p.G620D .
MFE319 SNV: p.L473P .
NCIH146 SNV: p.K915N .
NCIH2172 Insertion: p.E145GfsTer3 .
NCIH23 Insertion: p.M295IfsTer5
SNV: p.M295I		 .
OE33 SNV: p.E680D .
OSRC2 SNV: p.D598Y .
RPMI7951 SNV: p.E1003K .
SW620 SNV: p.A687V .
TCCSUP SNV: p.W896Ter .
UACC62 SNV: p.G858E .
YSCCC SNV: p.E995Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P21
 Probe Info  		11.16  LDD0408  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0158  P27 BxPC-3 11.16  LDD0408  [1]

References

1 Integrated phenotypic screening and activity-based protein profiling to reveal potential therapy targets of pancreatic cancer. Chem Commun (Camb). 2019 Jan 31;55(11):1596-1599. doi: 10.1039/c8cc08753a.