Details of the Target

General Information of Target

Target ID LDTP01386
Target Name E3 ubiquitin-protein ligase NEURL1 (NEURL1)
Gene Name NEURL1
Gene ID 9148
Synonyms
NEURL; NEURL1A; RNF67; E3 ubiquitin-protein ligase NEURL1; EC 2.3.2.27; Neuralized-like protein 1A; h-neu; h-neuralized 1; RING finger protein 67; RING-type E3 ubiquitin transferase NEURL1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPA
TPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGA
LRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFH
RINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLR
READDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALR
AGAHVRILDEQTVARVEHGRDERALVFTSRPVRVAETIFVKVTRSGGARPGALSFGVTTC
DPGTLRPADLPFSPEALVDRKEFWAVCRVPGPLHSGDILGLVVNADGELHLSHNGAAAGM
QLCVDASQPLWMLFGLHGTITQIRILGSTILAERGIPSLPCSPASTPTSPSALGSRLSDP
LLSTCSSGPLGSSAGGTAPNSPVSLPESPVTPGLGQWSDECTICYEHAVDTVIYTCGHMC
LCYACGLRLKKALHACCPICRRPIKDIIKTYRSS
Target Bioclass
Enzyme
Subcellular location
Cytoplasm, perinuclear region
Function
Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; inhibits malignant cell transformation of medulloblastoma (MB) cells by inhibiting the Notch signaling pathway.
Uniprot ID
O76050
Ensemble ID
ENST00000369780.9
HGNC ID
HGNC:7761

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.G212C; p.A348T .
HCT116 Deletion: p.L58SfsTer51 .
HS936T SNV: p.P99S .
MIAPACA2 Substitution: p.W201_A202delinsTer .
MOLT4 SNV: p.A528T .
SW756 SNV: p.I450L .
U118MG SNV: p.G438R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C143(1.33)  LDD2440  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 LN-18 C143(1.33)  LDD2440  [1]
 LDCM0023  KB03 LN-18 C143(1.76)  LDD2857  [1]
 LDCM0024  KB05 LN-18 C143(1.49)  LDD3274  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840